Medicine

Progressing ASO treatments from development to application

.Contending interests.R.S., M.S., H.G. as well as A.A.R. are organizers of the 1M1M project. H.G. and also A.A.R. are actually panel of supervisors members and also R.S., M.S. and also A.A.R. are members of the scientific advisory board of N1C. A.A.R. makes known work by LUMC, which possesses licenses on exon-skipping innovation, several of which has actually been actually certified to BioMarin and consequently sublicensed to Sarepta. As co-inventor of several of these licenses, A.A.R. was actually allowed to a portion of aristocracies. A.A.R. better divulges functioning as ad hoc expert for PTC Therapies, Sarepta Therapies, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco as well as Astra Zeneca. Previously 5 years, A.A.R. also performed ad hoc speaking to for Alpha Anomeric. A.A.R. additionally reports membership of the clinical boards of advisers of Eisai, Hybridize Rehabs, Silence Therapies, Sarepta Therapeutics, Sapreme as well as Mitorx. Over the last 5 years, A.A.R. was additionally a scientific advisory board member for ProQR. Commission for A.A.R. u00e2 s consulting as well as urging activities is paid out to LUMC. Over the last 5 years, LUMC likewise got speaker gratuity coming from PTC Therapies, Alnylam Netherlands, Italfarmaco and also Pfizer and moneying for contract research from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Project backing is actually received from Sarepta Rehabs and Entrada by means of unregulated grants. H.G. possesses absolutely nothing to reveal in relation to the topics covered in this particular document. Previously 5 years, he has additionally gotten working as a consultant gratuity from UCB. M.S. obtained working as a consultant gratuity from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa over the last 5 years, all unconnected to today composition. R.S. possesses absolutely nothing to make known in connection with the subjects covered in this particular manuscript. She has acquired speaker and/or working as a consultant gratuity or funding payments from Abbvie, Bial, STADA and also Everpharma before 5 years.